Hansenula polymorpha – originally, among others, obscure from souring orangeness juice - equals a single cell yeast with excellent characteristics for the production of therapeutical, recombinant proteins, vaccines and industrial enzymes. H. polymorpha is taxonomically a species of the Saccharomycetaceae family line. The extending taxonomy monographs comply a recent proposal to merge the genera Pichia and Hansenula and to re-name H. polymorpha as Pichia angusta. Exercises are bio-pharmaceuticals care insulin for the treatment of diabetes, hirudin as an decoagulant, hepatitis B vaccines or IFN α-2a for the treatment of hepatitis C, which cause embodied successfully brought out and marketed exploitation this bewitching expression system.
Hansenula polymorpha (Pichia angusta) belongs to a limited number of methylotrophic yeast species (yeasts that can grow on methanol). The range of methylotrophic yeasts includes Candida boidinii, Pichia methanolica, Pichia pastoris and Hansenula polymorpha. However, galore scientists want to maintain the common name H. polymorpha.
Moreover, the H. polymorpha expressed recombinant gp96 can effectively induce HBV-specific CTL response in immunized mice while Escherichia coli-expressed gp96 cannot. Our results therefore may provide bases for structure and functional studies of gp96 and thereby potentially expedite the development of gp96-based vaccines for immunotherapy of cancer or infectious diseases.
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