How to Buy Streptomyces

Streptomyces is the largest genus of Actinobacteria and the type genus of the family
Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described.
Streptomycetes are the most widely studied and well known genus of the actinomycete
family. As with the other Actinobacteria, streptomycetes are gram-positive, and have
genomes with high GC-content. Found predominantly in soil and decaying vegetation, most
streptomycetes produce spores, and are noted for their distinct "earthy" odor which
results from production of a volatile metabolite, geosmin.
The Sanger Institute completed the sequencing of the Streptomyces coelicolor A3(2) genome
in collaboration with Prof. David Hopwood of the John Innes Centre. The sequence was
generated using a clone-by-clone approach,initially using cosmids generated and mapped by
David Hopwood's group at the John Innes Centre, and latterly using a BAC library to fill
gaps and confirm the map.
Streptomycetes usually inhabit soil and are important decomposers. They also produce more
than half of the world's antibiotics, and are consequently invaluable in the medical
field. This organism is a well known producer of the anti-parasitic agent avermectin
which is widely used to rid livestock of worm and insect infestations and to protect
large numbers of people from river blindness in sub-Saharan Africa. There are also two
genome projects in the works for Streptomyces scabiei and Streptomyces ambofaciens.
Underpinning this work is a continuing investigation of the basic genetics of
streptomycetes and their accessory genetic elements, and the development of techniques of
genetic analysis and manipulation. The focal point is the model organism, Streptomyces
coelicolor A3(2).
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