Wednesday, May 20, 2015

Introduction of Hypericin


Hypericin is a naphtodianthrone, a red-coloured anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.
The crude extract of Hypericum is a weak inhibitor of MAO-A and MAO-B. Isolated hypericin does not display this activity, but does have some affinity for NMDA receptors. This points in the direction that hyperforin is responsible for the MAOI effect.
CAS:     548-04-9
Molecular Formula:C30H16O8
Formula Weight:504.44
from:Acridine Raw Material

Monday, May 18, 2015

what is the Cholesterol?



Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals.It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and fat-soluble vitamins including Vitamin A, Vitamin D, Vitamin E, and Vitamin K. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Although cholesterol is an important and necessary molecule for animals, a high level of serum cholesterol is an indicator for diseases such as heart disease.
CAS:57-88-5
Molecular Formula:C27H46O
Formula Weight:     386.65
from:Acridine Raw Material

Wednesday, May 13, 2015

what is the uses of Ethylenediaminetetraacetic acid?


Ethylenediaminetetraacetic acid, widely abbreviated as EDTA (for other names, see Table) is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve scale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA.
Lead poisoning and heavy metal toxicity
Chelation therapy using EDTA is the medically accepted treatment for lead poisoning. Injected intravenously and once in the bloodstream, EDTA traps lead and other metals, forming a compound that the body can get rid of in the urine. The process generally takes 1 - 3 hours. Other heavy metal poisonings treated with chelation include mercury, arsenic, aluminum, chromium, cobalt, manganese, nickel, selenium, zinc, tin, and thallium. Chelating agents other than EDTA are also used to clear several of these substances from the bloodstream.
Heavy metal toxicity in humans has been associated with many health conditions, including heart disease, attention deficit/hyperactivity disorder (ADHD), Alzheimer's disease, immune system disorders, gastrointestinal disorders (including irritable bowel syndrome, or IBS), and autism.
Digoxin toxicity
EDTA has also been used to treat digoxin toxicity, although most doctors prefer to use other methods. In this case, EDTA helps remove excess levels of digoxin, a medication that is used to treat abnormal rhythms of the heart.
from:Acridine Raw Material

Monday, May 11, 2015

what is the Quinine sulfate dihydrate?



Name:Quinine sulfate dihydrate CAS:6119-70-6 Molecular Formula:C40H48N4O4·H2SO4·2H2O Formula Weight:782.96 Description: Melting point:233-235 ºC Chemical property:white crystalline powder Product Categories:Antiparasitic / Antiprotozoal / AnthelminthicVoltage-gated Ion Channels;Monovalent Ion Channels; Potassium Channel Modulators;Antiparasitic / Antiprotozoal / AnthelminthicBiochemicals and Reagents from:Acridine Raw Material