Acyclovir impurity some utility

Acyclovir impurity is a synthetic purine nucleoside analogs. Caused by herpes simplex virus is mainly used for a variety of infections that can be used in primary or recurrent skin, mucous membranes, genital herpes infection and immunodeficiency HSV infection occurred. For the treatment of HSV encephalitis drug of choice to reduce morbidity and mortality are better than vidarabine. Can be used for herpes zoster, EB virus, and immune deficiency complicated by infections such as chickenpox. Local only for skin, Acyclovir impurity skin absorb less.

Indications:
1 herpes simplex virus infection: oral genital herpes infection for primary and recurrent cases; cases of recurrent oral on the materials used for prophylaxis. Injection for the immunocompromised. Onset and recurrent mucocutaneous infections and prevention of recurrent cases; also used for the treatment of herpes simplex encephalitis.
2 herpes zoster: oral for normal immune function with herpes and immunocompromised mild cases of treatment. Injections for severe immunocompromised patients with herpes treatment.
3 immunocompromised chickenpox treatment.
4 topically to herpes simplex virus-induced early genital herpes infection and immunodeficiency self-limiting mucocutaneous herpes simplex initial treatment and recurrence.
5 with its sodium treatment of acute retinal necrosis. Nucleotide antiviral drugs for the treatment of:
① herpes simplex keratitis;
② herpes simplex;
③ with herpes;
④ with its sodium salt treatment of acute retinal necrosis. Mainly for the herpes simplex virus and zoster virus causes superficial, deep keratitis.


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Lysipressin Acetate some of the information

Chinese name: Lysipressin Acetate
Chinese Synonyms: Acetic acid Lai vasopressin; lysine vasopressin (LYSPRESSIN); Lypressin; Lai vasopressin; CYS-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2 (DISULFIDE BRIDGE: CYS1-CYS6); acetic acid lysine vasopressin 50-57-7; acetic acid lysine vasopressin LYSIPRESSINACETATE
English name: Lypressin
English Synonyms: (8-lysine) vasopressin; 8-l-lysine-vasopressi; 8-l-lysinevasopressin; diapid; l-lysinevasopressin; lysinepitressin; postacton; syntopressin
CAS Number: 50-57-7
Formula: C46H65N13O12S2
MW: 1056.22
EINECS Number: 200-050-5
Mol File: 50-57-7.mol
Lysipressin Acetate are mammals such as pigs, etc. One of the posterior pituitary hormone secretion, which consists of hypothalamic nucleus of the hypothalamus produces and then by axonal transport to the posterior pituitary, and then secreted by the posterior lobe. Containing a nine amino acid residues of the active peptides, because of which the two cysteines linked by a disulfide as a cystine (Cys-Cys), also known as timing octapeptide. In addition from the posterior pituitary extract, but also to synthetic, it has anti-diuretic and blood pressure rise, therefore called antidiuretic hormone (antidiuretic hormone) or vasopressin (vasopressin)



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What is Aviptadil Acetate?

Cas No. 40077-57-4
Name ：Aviptadil Acetate
Sequence ： His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Molecular Formula ： C147H238N44O42S
Molecular Weight ： 3325.87
Purity (HPLC) ：98.0%
Appearance ： White powder
Single Impurity(HPLC) ： 1.0%
Amino Acid Composition ： 10% of theoretical
Peptide Content(N%)： 80%(by %N)
Water Content(Karl Fischer) ： 6.0%
Acetate Content(HPIC)： 15.0%
Mass Balance 95.0～105.0%



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Protirelin Acetate Product Overview

Name: Protirelin Acetate
ProtirelinAcetate active substances: This product is to stimulate the pituitary secretion of thyroid-stimulating hormone (TSH) and prolactin (PRL) CAS NO :24305-27-9 sequence: Pyr-His-Pro-NH2 Molecular formula: C16H22N6O4 MW: 362.39
1 The diagnosis of Graves' disease.
2 the differential diagnosis of thyroid dysfunction lesion (primary or secondary pituitary insufficiency).
3. Determine the hypothalamus - pituitary - thyroid axis function tests pituitary reserve function. Product parameters:
1.Purity (HPLC)
≥ 99%. And ≥ 99.5% 2.Appearance
White powder3.Single Impurity (HPLC)
1.0% max4.Amino Acid Composition
± 10% of theoretical5.Peptide Content (N%)
≥ 80.0% 6.Water Content (Karl Fischer)
≤ 5.0% 7.Acetate Content (HPIC)
≤ 10.0% 8.MS (ESI)
Consistent9.Mass Balance



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Alarelin Acetate inspection methods

Characters: Alarelin Acetate is a white or almost white powder; odorless, hygroscopic This product is dissolved in methanol, slightly soluble in 1% acetic acid solution dissolved specific rotation of this product, accurately weighed, add 1% acetic acid solution, dissolved and diluted quantitatively per 1ml solution containing 5mg, determined by law (Appendix Ⅵ E), by water, no matter acetate calculated specific rotation of -46 ° to -56 °. Absorption coefficient of this product, accurately weighed, dissolved in water and diluted quantitatively containing 0.1mg per 1ml of the solution, according to the UV - visible spectrophotometry (Appendix Ⅳ A), the absorbance was measured at a wavelength of 279nm by water, No acetic acid was calculated, the absorption coefficient (E 1% / 1cm) of 52-57.
Clarity and color of solution of this product 20mg, 2ml dissolved in water, the solution should be clear and colorless; such as color, with yellow on the 2nd standard colorimetric solution (Appendix Ⅸ A), not deeper. Take some acetic acid, accurately weighed, add diluent [Mobile phase A-mobile phase B (95:5)] dissolved and diluted 1ml each containing about 10mg solution as the test solution; Another ice acetic acid amount, accurately weighed, add Diluent 1ml each containing about 0.60mg solution as the reference solution. High performance liquid chromatography Governance (Appendix Ⅴ D) determination, with octadecylsilane bonded silica as a filler, phosphoric acid (phosphate take 0.7ml, add water 1000ml, with sodium hydroxide to adjust pH to 3.0) as mobile phase A, methanol as mobile phase B, gradient elution, detection wavelength was 210nm. Number of theoretical plates calculated peak acetate, not less than 2000. Gradient elution procedure is as follows: Time (min) Mobile phase A (%) mobile phase B (%) 0 95 5 5 50 50 20 50 50 25 95 5 precise amount of the reference solution and the test solution 20μl, were injected liquid chromatograph, record the chromatograms, the external standard method with peak area calculation. Acetic acid containing not more than 7.5%. Amino acid ratio of this product, plus 6mol / L hydrochloric acid solution at 110 ℃ after 24 hours hydrolysis with a suitable amino acid analysis ceremony measured by HPLC, the test with each amino acid alanine molar ratio should meet the following requirements : 0.7 to 1.0 of serine, glutamic acid is 0.9 to 1.1, proline 0.8 to 1.0, 0.9 to 1.1 leucine, tyrosine 0.9 to 1.1, 0.9 to 1.1 histidine, arginine 0.9 to 1.1. For substances of this product, add water containing 0.5mg per 1ml of solution as the test solution; precise amount of 1ml, 100ml flask, diluted with water to the mark, shake, as the control solution. According to the determination under chromatographic conditions, take control solution 20μl into the liquid chromatograph, adjust the sensitivity, the principal component chromatographic peak height of about 50 per cent of full scale; precise amount of the reference solution and the test solution 20μl , were injected into the liquid chromatograph, record the chromatograms to the main component peak retention time of 2 times, the test solution chromatogram, except the solvent peak, a single impurity peak area no larger than the control solution peak area of ​​2 times. The impurity peak area and peak area shall not be greater than the control solution 5 times (the main component of any less than the control solution peak area 0.05 times the peak to be negligible). Water to remove the goods, according to the determination (Appendix Ⅷ M first method A). Water containing not more than 7.0%.



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The Lysipressin Acetate Products

Name: Lysipressin Acetate
English Name: Vasopressin ,8-L-lysine-
Cas Number: 50-57-7
Alias: 9 - Lai vasopressin LVP; acetate Lai vasopressin; Lai vasopressin
Formula: C46H65N13O12S2
MW: 1056.22
EINECS: 200-050-5
Chemical properties:
Lysipressin Acetate traits:
This product is a synthetic vasopressin Lai colorless and transparent solution pH3.7 ~ 4.3, containing sodium acetate buffer, antibacterial agent triclosan methyl tert-butyl alcohol and sodium chloride. Vasopressin has a natural variety of biological activity per unit depends vasopressin antidiuretic effect equivalent to the human "fine vasopressin" half of its vasoconstrictor properties only in the application of high doses only apparent. Duration of action than diabetes insipidus stop short, only about 4 hours.
Lysipressin Acetate use: suitable for medium and mild pituitary diabetes insipidus.
Description:
1.Lysipressin Acetate overview:
The goods are mammals such as pigs, etc. One of the posterior pituitary hormone secretion, which consists of hypothalamic nucleus of the hypothalamus produces and then by axonal transport to the posterior pituitary, and then secreted by the posterior lobe. Containing a nine amino acid residues of the active peptides, because of which the two cysteines linked by a disulfide as a cystine (Cys-Cys), also known as timing octapeptide. In addition from the posterior pituitary extract, but also to synthetic, it has anti-diuretic and blood pressure rise, therefore called antidiuretic hormone (antidiuretic hormone) or vasopressin (vasopressin).
2 physiological functions:
Mainly to promote renal tubular reabsorption of water; also causes including coronary artery, pulmonary artery, including systemic small artery contraction, blood pressure. Elevated blood pressure and heart activity in view of the adverse, it is mainly used in clinical deficiency caused by the anti-diuretic hormone treatment of diabetes insipidus, but renal polyuria invalid.
3 lysine vasopressin (50-57-7) Usage and dosage:
Can be administered subcutaneously, intramuscularly; also be made of the pituitary nasal spray powder and other products. Each time the nasal spray one or two, three to five times a day. Stimulation of the nasal mucosa than diabetes insipidus stop powder for the light.
4 adverse reactions and precautions:
 Because no heterosexual protein, so allergic reactions than animal extracted vasopressin small. Common ulcerative epistaxis. Coronary artery aneurysms and epilepsy hanged.
5 Formulation:
5mL / bottle (each containing 50 mL vasopressin units).



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About the Eptifibatide Acetate

Brief Description

Eptifibatide(Integrilin)AcetateMolecular Formula: C35H49N11O9S2

Molecular Weight: 831.96Sequence: (Mpr-Harg-Gly-Asp-Trp-Pro-Cys)-NH2SPECIFICATIONS:1 .Appearance:Whitepowder

2.SpecificOpticalRotation(c=1,HAc,ByAnhydrous,AceticAcid-free) :-78~-88°

Product Attributes

Related attributes of Eptifibatide Acetate:

Place of Origin:Sichuan China (Mainland)Purity:more than 98%

Detailed Description

Detailed addition to Eptifibatide Acetate:

Eptifibatide(Integrilin) Acetate

Molecular Formula: C35H49N11O9S2

Molecular Weight: 831.96

Sequence: (Mpr-Harg-Gly-Asp-Trp-Pro-Cys)-NH2

SPECIFICATIONS:

1 .Appearance :White crumb

2 .Specific Optical Rotation(c=1,HAc,By Anhydrous, Acetic Acid-free) :-78~-88°

3 .Water Content(Karl Fischer) :≤8.0%

4 .Acetate Content(by HPLC) :≤15.0%

5 .Amino Acid Composition :±10% of abstract

6 .Purity(by HPLC) :≥98.0%

7 .Single Impurity(by HPLC) :≤1.0%

8 .Peptide Content(by %N) :≥80%

9 .Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%

10.Bacterial Endotoxins :≤5EU/mg

Packing:plastic canteen (dedicated for peptide packing) or bottle vial, abundance according to customer's detail requirement.

Storage:a cool(2~8 amount C) & dry abode adequate from light, accumulate amalgamation abutting if not in use.

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