Monday, June 11, 2012

Specifications of methylprimaquine


methylprimaquine
Systematic name:Pentanoic acid, 4-[(6-methoxy-4-methyl-8-quinolinyl)amino]-
Molecular formulae :C16H20N2O3
Molecular weight:288
Chemical abstracts number:104594-71-0
4-Methylprimaquine (4-MPQ), an 8-aminoquinoline antimalarial drug, was subjected to microbial metabolism studies in an accomplishment to isolate, identify, and adumbrate the apparent beastly metabolite(s). Preliminary screening with a amount of strains of Aspergillus adumbrated that several breed were able of metabolizing 4-MPQ to one above metabolite based on thin-layer chromatographic analysis. Preparative calibration about-face of 4-MPQ application whole-cell suspensions of Aspergillus ochraceus afforded one above metabolite (4-MPQ-I). Based on spectroscopic and actinic evidence, the anatomy of the metabolite is proposed as 6-methoxy-8-(3-carboxyl-l-methylpropylamino)-lepidine.
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