Teriparatide Acetate for patients suffering from severe osteoporosis , the drug is also being evaluated for the treatment of osteogenesis imperfecta aspects of efficacy in clinical trials.
There should not be elevated to patients at risk of suffering from osteosarcoma open with Teriparatide Acetate. Such patients include those suffering from Paget's bone disease (Paget's Disease of bone, osteitis deformans ) in patients with unexplained elevated serum alkaline phosphatase in patients in patients not yet closed epiphyseal plate , or related to bone radioactive treatment of patients.
Side effect
The most common side effects are nausea, leg cramps and dizziness . The main risk for Teriparatide Acetate is to increase the risk of suffering from osteosarcoma , at least in rats, the results of experimental studies to see is this . After the listing of the drugs , there have been very little about the risk of bone tumors and reported cases of osteosarcoma .
Mechanism
Teriparatide Acetate part of the human parathyroid hormone , the amino acid sequences 1-34 , complete human parathyroid hormone containing 84 amino acids . Endogenous parathyroid hormone in bone and kidney the primary regulator of calcium and phosphorus metabolism . PTH to increase the calcium concentration in serum , accompanied by an increase in calcium concentration , bone absorption of calcium is also part of the increase . Thus, the long-term elevated PTH , will consume bone saved. However , exposure to intermittent PTH activates osteoblasts, osteoclasts more so . Thus, once daily injections of teriparatide has a secondary net effect of new bone formation leading to bone density increased inorganic matter .
Teriparatide Acetate is the first one , but also to the current position of the only one FDA-approved treatment for osteoporosis, a drug to stimulate new bone formation .
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