Polymyxin B Sulphate is antibiotic derived from a strain of Bacillus polymyxa. Polymyxin B Sulphate is a sulfate salt of the least toxic member of the polymixin group. Polymyxin B (Sulphate) is bacteriocidal for many gram negative bacteria. Polymyxin B (Sulphate) is a cationic, basic peptide contains fatty acid D-6-methyloctan-1-oic acid and amino acids L-threonine and L-diaminobutyric acid. Polymyxin B Sulphate is used in the treatment of various systemic, urinary tract, otic, ophthalmic and cutaneous infections due to susceptible gram -ve bacteria. Polymyxin B (Sulphate) is administered orally, parentrally and topically, but nowadays, rarely used parentrally due to its potential for causing nephrotoxicity and/or neurotoxicity. Polymyxin B (Sulphate) is more commonly administered as either a topical or otic agent in combination with neomycin or bacitracin. Polymyxin B (Sulphate) is also available in ophthalmic solutions in combination with either trimethoprim B or in combination with bacitracin and neomycin. Polymyxin B is also used in combination with neomycin as a urinary tract irrigant. Polymyxin B was originally approved by the FDA in 1951.
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CAS No.: 1405-20-5
M.F.: C56H98N16O13. H2SO4
M.W.: 1301.56
DESCRIPTION: WHITE TO ALMOST WHITE POWDER,HYGROSCOPIC.
SOLUBILITY: FREELY SOLUBLE IN WATER;SLIGHTLY SOLUBLE IN ALCOHOL.
IDENTIFICATION
LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST
A REDDISH VIOLET COLOR IS PRODUCED
TEST FOR SULFATE
PH(2%): 5.0~7.0
PH(0.5%): 5.0~7.5
SPECIFIC ROTATION: -78°- -90°
LOSS ON DRYING: NOT MORE THAN 7.0%
PHENYLALANINE: 9.0%~12.0%
More about: Polymyxin B Sulphate
Read more: Bacteria
M.F.: C56H98N16O13. H2SO4
M.W.: 1301.56
DESCRIPTION: WHITE TO ALMOST WHITE POWDER,HYGROSCOPIC.
SOLUBILITY: FREELY SOLUBLE IN WATER;SLIGHTLY SOLUBLE IN ALCOHOL.
IDENTIFICATION
LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST
A REDDISH VIOLET COLOR IS PRODUCED
TEST FOR SULFATE
PH(2%): 5.0~7.0
PH(0.5%): 5.0~7.5
SPECIFIC ROTATION: -78°- -90°
LOSS ON DRYING: NOT MORE THAN 7.0%
PHENYLALANINE: 9.0%~12.0%
More about: Polymyxin B Sulphate
Read more: Bacteria
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