What is 3,5-Dichloro-4-pyridinone？

CAS:17228-70-5

Molecular formula:C5H3Cl2NO

Molecular weight:163.99

Appearance:White or yellowish crystalline powder

 Use:The intermediate of Cefazedone, cefazolin

Product description:3,5-Dichloro-4-pyridinone is a white or yellowish crystalline powder, and used as the intermediate of Cefazedone.

What is Camellia sinensis?

Camellia sinensis is the breed of bulb whose leaves and blade buds are acclimated to aftermath the accepted cooler tea. It is of the brand Camellia (Chinese: 茶花; pinyin: Cháhuā, literally: "tea flower"), a brand of beginning plants in the ancestors Theaceae. White tea, chicken tea, blooming tea, oolong, pu-erh tea and atramentous tea are all harvested from this species, but are candy abnormally to attain altered levels of oxidation. Kukicha (twig tea) is aswell harvested from Camellia sinensis, but uses twigs and stems rather than leaves. Common names cover tea plant, tea shrub, and tea timberline (not to be abashed with Melaleuca alternifolia, the antecedent of tea timberline oil).
There are two above varieties acclimated for tea, Chinese tea, Camellia sinensis var. sinensis, and Assam tea, Camellia sinensis var. assamica.

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From:Lactic acid bacteria

What is Rapamycin?

Rapamycin (RAPA) is a new type of large ring lactone class immunosuppressants. Rapamycin factor receptor blocking signal transduction through different cells, block the T cell and other cell from G1 phase to S phase process, thereby immunosuppressive effect into full play. From the point of clinical application, rapamycin has good anti-rejection effect, and with cyclosporine A (CsA) and FK506 immune inhibitors have good synergy, is A kind of good curative effect, low toxicity, no new immunosuppressant nephrotoxicity. In March 2010, the United States, according to a study at the university of Texas rapamycin can be used in the treatment of alzheimer's disease, the drug composition are also present in the Easter island secretion of the bacteria in the soil.

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From:Lactic acid bacteria

What is Tacrolimus?

Tacrolimus and FK506, from Streptomyces (Streptomyces tsukubaensis) isolated from the fermentation product, its chemical structure is 23 yuan ring lactone class antibiotic. As a powerful new immunosuppressants, mainly by inhibiting the release of interleukin - 2-2 (L), fully inhibit the role of T cells, a ring of spore (CsA) 100 times stronger. In recent years, as a line of the liver and kidney transplantation medicine, in 14 countries such as Japan, the United States. Clinical trials showed that the heart, lung, intestine, bone marrow transplant in the application has a good curative effect. And FK506 in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE) and autoimmune autoimmune diseases such as eye disease also play an active role.

Indications: liver, heart, kidney and bone marrow transplant patients with immunosuppressive drugs of choice, after transplantation rejection of traditional immunosuppression solution resistance, also can choose the drug. Adverse reactions are similar to those of cyclosporine.

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From:Lactic acid bacteria

What is Cefodizime？

Cefodizime is a third bearing cephalosporin with a ample spectrum of antibacterial activity. Administered intravenously or intramuscularly, cefodizime 1 to 4g circadian for an boilerplate of 7 to 10 canicule produced analytic cure in 80 to 100% of patients (adults, aged or children) with high or lower respiratory amplitude infections or urinary amplitude infections, and in allusive trials cefodizime was as able as added third bearing cephalosporins. A individual dosage of cefodizime 1 or 2g is aswell advantageous in alleviative lower urinary amplitude infections, decidedly apprehensible infections, with a amount of analytic success of 72 to 88%. Urogenital gonorrhoea, whether acquired by β-lactamase bearing or non-β-lactamase bearing Neisseria gonorrhoeae, is actual finer advised by individual dosage analysis with intramuscular cefodizime 0.25 to 1g (virtually 100% cured). Basic abstracts from a baby amount of patients announce that cefodizime may aswell be advantageous in the analysis of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or analysis of surgical infections.
The analytic adeptness of cefodizime in allegory with added third bearing cephalosporins is above to that predicted from in vitro results. This above action of cefodizime may be accompanying to the almost continued abolishment half-life of the biologic or its adeptness to adapt some functions of the allowed arrangement — a potentially important award apprehension added investigation.
Cefodizime is able-bodied acceptable and has a tolerability contour agnate to added associates of its chic with systemic adverse contest getting primarily gastrointestinal or dermatological.
Thus, bound allusive studies announce cefodizime has the abeyant to become a advantageous another to accepted antimicrobial analysis for the analysis of a array of infections. Cefodizime may be added acceptable to administrate than some added agents of its chic as it may be accustomed already or alert daily. While there are no trials comparing cefodizime to added third bearing cephalosporins in immunosuppressed populations, basic advice indicates cefodizime may be advantageous in this group.
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Iloperidone metabolite P95 of basic information

English name: Iloperidone Carboxylic Acid

English synonyms: Iloperidone Carboxylic Acid; 4 - [3 - (4 - (6 - Fluoro - 1, 2 - benzisoxazol - 3 - yl) - 1 - piperidinyl] propoxy] - 3 - Methoxybenzoic Acid; P 95-12113; Iloperidone metabolite P95

CAS no. : 475110-48-6

Molecular formula: C23H25FN2O5

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From:Natural herbal extracts

Some indications Ubenimex

Indications: Ubenimex can enhance immune function, used for cancer chemotherapy, radiotherapy adjuvant treatment of senile immune defects. Can be combined with chemotherapy, radiotherapy and combined application of leukemia, multiple myeloma, myelodysplastic syndrome, and hematopoietic stem cell transplantation, and other solid tumors.
Toxicology: Ubenimex from Streptomyces (Streptomyces ofivorecticuli) separating the resulting culture medium containing compounds competitively inhibit aminopeptidase B (aminopeptidase N/CD13) and leucine peptidase (Leucineamino-Peptidase). Enhance T cell function, the NK cell killing vitality, and to lead to increased synthesis of colony-stimulating factor to stimulate the regeneration of bone marrow cells and differentiation. This product can interfere with the metabolism of tumor cells, inhibition of tumor cell proliferation, apoptosis and activation of human immune function, stimulating cytokine production and secretion of anti-tumor effect of promoting cell generation and proliferation.


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From:Lactic acid bacteria

Teriparatide Acetate role and side effects

Teriparatide Acetate for patients suffering from severe osteoporosis , the drug is also being evaluated for the treatment of osteogenesis imperfecta aspects of efficacy in clinical trials.
There should not be elevated to patients at risk of suffering from osteosarcoma open with Teriparatide Acetate. Such patients include those suffering from Paget's bone disease (Paget's Disease of bone, osteitis deformans ) in patients with unexplained elevated serum alkaline phosphatase in patients in patients not yet closed epiphyseal plate , or related to bone radioactive treatment of patients.
Side effect
The most common side effects are nausea, leg cramps and dizziness . The main risk for Teriparatide Acetate is to increase the risk of suffering from osteosarcoma , at least in rats, the results of experimental studies to see is this . After the listing of the drugs , there have been very little about the risk of bone tumors and reported cases of osteosarcoma .
Mechanism
Teriparatide Acetate part of the human parathyroid hormone , the amino acid sequences 1-34 , complete human parathyroid hormone containing 84 amino acids . Endogenous parathyroid hormone in bone and kidney the primary regulator of calcium and phosphorus metabolism . PTH to increase the calcium concentration in serum , accompanied by an increase in calcium concentration , bone absorption of calcium is also part of the increase . Thus, the long-term elevated PTH , will consume bone saved. However , exposure to intermittent PTH activates osteoblasts, osteoclasts more so . Thus, once daily injections of teriparatide has a secondary net effect of new bone formation leading to bone density increased inorganic matter .
Teriparatide Acetate is the first one , but also to the current position of the only one FDA-approved treatment for osteoporosis, a drug to stimulate new bone formation .



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From:Natural food additive

Ni-Mo hydrodesulfurization agent -related information

Ni-Mo hydrodesulfurization agent is activated to acclimatized gas, abounding petroleum gas,refinery gas.Strong acerbic sites on the credible of mesoporous MCM-41 were generated by ion-exchanging siliceous MCM-41 with attenuated HNO3 band-aid (0.5 M). The XRF affirmation indicates that a lot of of the sodium cations absolute in MCM-41 can be removed by the proton exchange, and dealuminization was empiric during the proton exchange. The acidity of the mesoporous abstracts was characterized by bureau of NH3-TPD and the Hammett indicators. It is arise that new able acerbic sites (-5.6 > H0 > -8.2) were generated afterwards the ancient 2 h of ion bargain and that the after ion exchanges had little aftereffect on the absinthian properties. XRD patterns of the mesoporous abstracts advertise that the analysis of siliceous MCM-41 was bigger by HNO3 ion exchange. If Ni-Mo hydrodesulfurization abettor sulfides were authentic on the able solid acerbic (H+-MCM-41), top accomplishment in the hydrodesulfurization (HDS) of dibenzothiophene (DBT) was observed. However, the HDS action was decreased while the selectivity of biphenyl (BP) was increased, if H+-Si-MCM-41 was ion exchanged with Na2CO3 aqueous solution. TPR profiles of the authentic Ni-Mo oxides accede that the absinthian accomplishments of the supports abundantly admission the hydrogenation activities of the bimetallic oxides. The top accomplishment of H+-MCM-41-supported Ni-Mo catalysts may be attributed to the added hydrogenation activity.
The role of nickel in the action of bottomless Ni-Mo hydrodesulfurization abettor hydrodesulfurization catalysts
A alternation of bottomless nickel-molybdenum sulfide catalysts accoutrement the ambit 0–100 atom% nickel has been able by connected coprecipitation. Highly broadcast Ni3S2 is appropriate to play a role in hydrogen activation, appointment protons and electrons to the MoS2, and this may anatomy the o rigin of the accessory mechanism. The acceptable roles of the apostle are summarized.


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From:Catalyst chemistry

Etridiazole basic information

CAS No.: 2593-15-9
English name: ETRIDIAZOLE
English Synonyms: ETMT; KOLAN; Dwell; Koban; TRUBAN; Banrot; Etcmtb; MF-344; om2424; ETHAZOL
Chinese name: dimethylphenyl acrylate
Chinese Synonyms: Soil benomyl; chlorazol spirit; pause between interest; chlorazol Spirit / soil benomyl; dimethylphenyl acrylate; 5 - ethoxy-3 - trichloromethyl-1 ,2,4 - thiadiazole
CBNumber: CB0145031
Formula: C5H5Cl3N2OS
Molecular Weight: 247.53
MOL File: 2593-15-9.mol
Dimethylphenyl acrylate Chemical Properties
Flash Point: 154.5 ° C
Storage conditions: 0-6 ° C
Safety Information
Hazard Codes: T, N
Risk Codes: 21/22-23-40-50/53-20/21/22
Safety Instructions: 36/37-38-45-60-61
RIDADR: UN2810 6.1/PG 2
RTECS Number: XI3875000
Health Hazard: Burning produces toxic chlorine, sulfur oxide and nitrogen oxide gases
Storage features: Treasury ventilated low-temperature drying; separate storage and food ingredients
Extinguishing Media: Dry chemical, foam, sand


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From:Herbal extract