Product Use:
Use one: potent and selective aromatase inhibitors triazole, can inhibit the cytochrome P-450 enzyme aromatase depend thereby blocking the biosynthesis of estrogen, and estrogen to stimulate the growth of breast cancer cells the main factor.
Uses two: the treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy in women after menopause advanced breast cancer.
Pharmaceutical medical knowledge:
Indications: For anastrozole after tamoxifen and other anti-estrogen therapy still can not control in postmenopausal women with advanced breast cancer. On estrogen receptor-negative patients, if their right tamoxifen showed positive clinical response, consider using anastrozole.
ACTION: Anastrozole is a potent and selective non-steroidal aromatase inhibitors. Inhibit postmenopausal patients with adrenal androstenedione generated into estrone, which significantly reduced plasma levels of estrogen, resulting in inhibition of mammary tumor growth. In addition, anastrozole right adrenal corticosteroids or aldosterone generate no significant effect.
Pharmacokinetics: oral anastrozole absorbed quickly in the body about 40% of anastrozole and plasma protein binding, the majority metabolized into inactive products were excluded from the urine, about 10 per cent of the prototype anastrozole excluded from the urine . According to reports, healthy male volunteers after oral administration of 1mg, time to peak plasma concentration was 1.22 ± 0.46 hours, peak plasma concentration was 9.99 ± 3.24ng/ml, elimination half-life of 35.96 ± 14.17 hours.
Dosage: Tablets: orally once a day, every one (1 mg), with mild to moderate hepatic function or mild renal impairment in patients with generally Needless to adjust the dose.
More about:Arimadex (Anastrozole) manufacturer
From:Natural herbal extracts
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