Actinobacteria are a group of Gram-positive bacteria with high guanine and cytosine content. They can be terrestrial or aquatic. Actinobacteria is one of the dominant phyla of the bacteria. Analysis of glutamine synthetase sequence has been suggested for phylogenetic analysis of Actinobacteria.
Characteristics
Actinobacteria include some of the most common soil life, freshwater life, and marine life, playing an important role in decomposition of organic materials, such as cellulose and chitin, and thereby playing a vital part in organic matter turnover and carbon cycle. This replenishes the supply of nutrients in the soil and is an important part of humus formation.
Actinobacteria are well known as secondary metabolite producers and hence of high pharmacological and commercial interest. In 1940 Selman Waksman discovered that the soil bacteria he was studying made actinomycin, a discovery for which he received a Nobel Prize. Since then, hundreds of naturally occurring antibiotics have been discovered in these terrestrial microorganisms, especially from the genus Streptomyces.
Most Actinobacteria of medical or economic significance are in subclass Actinobacteridae, order Actinomycetales. While many of these cause disease in humans, Streptomyces is notable as a source of antibiotics.
Of those Actinobacteria not in Actinomycetales, Gardnerella is one of the most researched. Classification of Gardnerella is controversial, and MeSH catalogues it as both a gram-positive and gram-negative organism.
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