Yarrowia for Sale

Yarrowia lipolytica can be used to produce methane from lipids. It assimilates hydrocarbons and produces citric acid from n-alkanes, vegetable oils or glucose under aerobic conditions. Yarrowia is a fungal genus in the family Dipodascaceae. In yeasts and fungi growing in minimal medium, the two known ways to replenish the tricarboxylic acid cycle are the reaction catalyzed by pyruvate carboxylase and those catalyzed by isocitrate lyase and malate synthase, which form the glyoxylate bypass (Fig. 1).

The genus is monotypic, containing the single species Yarrowia lipolytica, a yeast. It can use unusual carbon sources, such as hydrocarbons. This makes it of industrial interest. The tricarboxylic acid cycle has an amphibolic role in metabolism.

Yarrowia lipolytica is routinely isolated from different food media (ie.cheeses, sausages). It functions not only as an oxidative device coupled to energy production but also provides building blocks for the synthesis of important molecules such as porphyrins and several amino acids (Fig. 1). Yarrowia lipolytica is very distantly related to the rest of the yeasts; instead it shares a number of common properties with filamentous fungi. It is a hemiascomycetous yeast and these yeasts represent a homogeneous phylogenetic group of eukaryotes with a relatively large diversity at physiological and ecological levels. It is a hemiascomycetous yeast and these yeasts represent a homogeneous phylogenetic group of eukaryotes with a relatively large diversity at physiological and ecological levels.

With their relatively small and compact genomes, yeasts offer a unique opportunity to explore eukaryotic genome evolution by comparative analysis of several species. Yeasts are widely used as cell factories, for the production of beer, wine and bread and more recently of various metabolic products such as vitamins, ethanol, citric acid, lipids, and for assimilation of hydrocarbons ie. This work, which represents the first multispecies exploration of genome evolution across an entire eukaryotic phylum, reveals the variety of events and mechanisms that have taken place, and should allow useful comparisons with other phyla of multicellular organisms when more genome sequences are determined.

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