Folinic acid is 5-formyl acquired of tetrahydrofolic acid. It is calmly adapted into added bargain derivatives of folic acid, so that this vitamin activity agnate to that of folic acid. Although the apparatus is not absolutely clear, the polyglutamylation methotrexate and dihydrofolate will play in cancerous beef as an important role in the careful reactivation of dihydrofolate reductase of folinic acerbic in accustomed cells.
Since it is not the activity of dihydrofolate reductase adapted for its conversion, its activity afflicted by drugs such as methotrexate Vitamin by the inhibition of this enzyme. This is the standpoint of classical accomplishment folinic acerbic therapy.Folinic accordingly some constructed purine / pyrimidine permits in the attendance of dihydrofolate reductase inhibition occur, so that a allotment of the DNA archetype can abide normal.
No comments:
Post a Comment