What is Teicoplanin?

Teicoplanin is an antibacterial acclimated in the prophylaxis and analysis of austere infections acquired by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a glycopeptide antibacterial extracted from Actinoplanes teichomyceticus, with a agnate spectrum of activity to vancomycin. Its apparatus of activity is to arrest bacterial corpuscle bank synthesis.
Teicoplanin is marketed by Sanofi-Aventis beneath the barter name Targocid.
Oral teicoplanin has been approved to be able in the analysis of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with commensurable ability with vancomycin.
Teicoplanin (TARGOCID , marketed by Sanofi Aventis Ltd) is in fact a admixture of several compounds, 5 above (named teicoplanin A2-1 through A2-5) and four accessory (named teicoplanin RS-1 through RS-4). All teicoplanins allotment a aforementioned glycopeptide core, termed teicoplanin A3-1 — a alloyed ring anatomy to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The above and accessory apparatus aswell accommodate a third carbohydrate atom — β-D-glucosamine — and alter alone by the breadth and anatomy of a side-chain absorbed to it.
Biosynthesis
Teicoplanin consists of a accumulation of 5 structures. These structures acquire a accepted aglycone, or core, consisting of seven amino acids that are apprenticed by peptide and ether bonds to anatomy a four ring system. These 5 structures alter by the character of the blubbery acyl side-chain absorbed to the sugar. The agent of these seven amino acids in the biosynthesis of teicoplanin was advised by 1H and 13C NMR. The studies announce amino acids AA1, AA2, AA4, AA5, and AA6 are acquired from tyrosine, and amino acids AA3 and AA7 are acquired from acetate. To be specific, teicoplanin contains 4-hydroxyphenylglycine and 3,5-dihydroxyphenylglycine residues, a chlorine atom absorbed on anniversary of the tyrosine residues, and three amoroso moieties, N-fatty acyl-β-D-glucosamine, N-acetyl-β-D-glucosamine, and D-mannose.
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